Canonical Wnt Signaling Is Critical to Estrogen-Mediated Uterine Growth
نویسندگان
چکیده
منابع مشابه
The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and Therapy
Precise regulation of signal transduction pathways is crucial for normal animal development and for maintaining cellular and tissue homeostasis in adults. The Wnt/Frizzled-mediated signaling includes canonical and non-canonical signal transduction pathways. Upregulation or downregulation of the canonical Wnt-signaling (or the Wnt/β-Catenin signal transduction) leads to a variety of human diseas...
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The epithelial-mesenchymal transition is essential in both embryonic development and the progression of carcinomas. Wnt signaling and cadherin-mediated adhesion have been implicated in both processes; clarifying their role will depend on linking them to rearrangements of cellular structure and behavior. beta-Catenin is an essential molecule both in cadherin-mediated cell adhesion and in canonic...
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Authors’ Affiliations: Unit of Molecular Oncology, Unit of in vivo Pharmacology, Department of Medicinal Chemistry, Department of Biomolecular Screening, Clinical Development and Department of Pharmacology, Siena Biotech Medicine Research Centre, Siena, Italy. Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. The F. M. Kirby Neurobiolo...
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Neither the mechanisms that govern lip morphogenesis nor the cause of cleft lip are well understood. We report that genetic inactivation of Lrp6, a co-receptor of the Wnt/beta-catenin signaling pathway, leads to cleft lip with cleft palate. The activity of a Wnt signaling reporter is blocked in the orofacial primordia by Lrp6 deletion in mice. The morphological dynamic that is required for norm...
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ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 2004
ISSN: 0888-8809,1944-9917
DOI: 10.1210/me.2004-0259